交感性眼炎的免疫遗传学研究。

Immunogenetic study of sympathetic ophthalmia.

作者信息

Shindo Y, Ohno S, Usui M, Ideta H, Harada K, Masuda H, Inoko H

机构信息

Department of Ophthalmology, Yokohama City University School of Medicine, Japan.

出版信息

Tissue Antigens. 1997 Feb;49(2):111-5. doi: 10.1111/j.1399-0039.1997.tb02723.x.

DOI:10.1111/j.1399-0039.1997.tb02723.x

PMID:9062965

Abstract

Sympathetic ophthalmia (SO) is very rare but it remains one of the most intractable eye diseases. In clinical manifestations and histopathologic features SO is known to resemble closely Vogt-Koyanagi-Harada's disease (VKH disease). We had reported that VKH disease was significantly associated with HLA-DRB104 and -DQB104 in Japanese patients. In this study, to investigate an HLA association with SO we performed HLA serological and PCR-based DNA typing in 16 patients and 50 healthy controls. Our study revealed that HLA-DRB104 (0405; Pc < 5 x 10(-4)), DQA103 (Pc < 5 x 10(-3)), and DQB1*04 (0401; Pc < 5 x 10(-4)) were significantly associated with SO as compared to the healthy controls but there was no significant difference in the frequencies of any DPB1 alleles between the patients and healthy controls. It can be postulated that not only the clinical manifestations but also the genetic predisposition of SO are very similar to those of VKH disease.

摘要

交感性眼炎（SO）非常罕见，但它仍然是最难治疗的眼病之一。在临床表现和组织病理学特征方面，已知交感性眼炎与Vogt-小柳-原田病（VKH病）极为相似。我们曾报道，在日本患者中，VKH病与HLA-DRB104和-DQB104显著相关。在本研究中，为了调查HLA与交感性眼炎的关联，我们对16例患者和50名健康对照进行了HLA血清学和基于PCR的DNA分型。我们的研究表明，与健康对照相比，HLA-DRB104（0405；Pc < 5 x 10(-4)）、DQA103（Pc < 5 x 10(-3)）和DQB1*04（0401；Pc < 5 x 10(-4)）与交感性眼炎显著相关，但患者和健康对照之间任何DPB1等位基因的频率均无显著差异。可以推测，不仅交感性眼炎的临床表现，而且其遗传易感性都与VKH病非常相似。