Lin X, Mellow M H, Southmayd L, Pan J, Chen J D
Thomas N. Lynn Institute for Healthcare Research, Integris Baptist Medical Center, Oklahoma City, Oklahoma 73112, USA.
Dig Dis Sci. 1997 May;42(5):898-906. doi: 10.1023/a:1018856112765.
Dysmotility and delayed emptying of the stomach have been reported in patients with chronic renal failure (CRF). The aim of this study was to investigate whether gastric myoelectrical activity was impaired in patients with CRF using electrogastrography. The electrogastrogram (EGG) was recorded in 24 symptomatic patients with CRF (15 with diabetes) and 12 normal subjects. Two 30-min EGG recordings before and after a test meal were analyzed using spectral analysis methods. It was found that patients with CRF showed a significantly lower percentage of normal 2-4 cpm slow waves in both fasting and fed states in comparison with healthy controls (in fasting state: 88.9 +/- 2.5% vs 67.4 +/- 6.6%/63.2 +/- 7.0%, P < 0.01; in fed state: 89.6 +/- 1.8% vs 64.6 +/- 6.2%/62.0 +/- 8.3%, P < 0.01; controls vs diabetic patients/nondiabetic patients). Both patient groups showed a significantly higher prevalence of the abnormal EGG, which was defined as the percentage of 2-4 cpm slow waves lower than 70% (fasting state: 8% vs 60%/56%, P < 0.01/0.05; fed state: 0% vs 53%/56%, P < 0.005/0.002; controls vs diabetic patients/nondiabetic patients). No significant difference was observed in the regularity of the gastric slow waves between the two patient groups. The healthy controls showed a significant increase in the dominant power and frequency of the EGG after the test meal. However, this increase was absent in the two patient groups. It was concluded that patients with chronic renal failure have abnormal gastric myoelectrical activity, including impaired regularity of the gastric slow wave and a failed increase in the power of the EGG at 3 cpm. Electrogastrography is an attractive noninvasive method for the study of gastric motility in patients with severe chronic renal failure.
慢性肾衰竭（CRF）患者中已报道存在胃动力障碍和胃排空延迟。本研究的目的是使用胃电图来调查CRF患者的胃肌电活动是否受损。对24例有症状的CRF患者（15例患有糖尿病）和12名正常受试者进行了胃电图（EGG）记录。使用频谱分析方法分析了试餐前后两个30分钟的EGG记录。结果发现，与健康对照组相比，CRF患者在空腹和进食状态下正常的2 - 4次/分钟慢波百分比均显著降低（空腹状态：88.9±2.5% 对67.4±6.6%/63.2±7.0%，P < 0.01；进食状态：89.6±1.8% 对64.6±6.2%/62.0±8.3%，P < 0.01；对照组对糖尿病患者/非糖尿病患者）。两组患者异常EGG的患病率均显著更高，异常EGG定义为2 - 4次/分钟慢波百分比低于70%（空腹状态：8% 对60%/56%，P < 0.01/0.05；进食状态：0% 对53%/56%，P < 0.005/0.002；对照组对糖尿病患者/非糖尿病患者）。两组患者之间胃慢波的规律性未观察到显著差异。健康对照组在试餐后EGG的主导功率和频率显著增加。然而，两组患者均未出现这种增加。得出的结论是，慢性肾衰竭患者存在异常的胃肌电活动，包括胃慢波规律性受损以及EGG在3次/分钟时功率未增加。胃电图是研究重度慢性肾衰竭患者胃动力的一种有吸引力的非侵入性方法。
