Muchnik S, Losavio A S, Vidal A, Cura L, Mazia C
Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.
Muscle Nerve. 1997 Jun;20(6):674-8. doi: 10.1002/(sici)1097-4598(199706)20:6<674::aid-mus3>3.0.co;2-5.
Recent reports have shown that patients with Lambert-Eaton myasthenic syndrome (LEMS) improve transiently after high-dose intravenous immunoglobulin (IVIG) administration. Information about the usefulness of IVIG for long-term treatment is rather scanty. Our findings demonstrate the efficacy of monthly IVIG courses at a dose of 0.4 g/kg/day for 5 days, in a 41-year-old patient with LEMS without detectable malignancy. Improvement in limb strength, peak expiratory flow rate, and electrophysiological parameters, as well as clinical signs following IVIG, was evident as early as 7 days after the first course and is still maintained at 24-months follow-up.
最近的报告显示，兰伯特-伊顿肌无力综合征（LEMS）患者在大剂量静脉注射免疫球蛋白（IVIG）后症状会短暂改善。关于IVIG长期治疗有效性的信息相当匮乏。我们的研究结果表明，对于一名41岁无明显恶性肿瘤的LEMS患者，每月进行一次为期5天、剂量为0.4 g/kg/天的IVIG疗程是有效的。早在第一个疗程后7天，肢体力量、呼气峰值流速和电生理参数以及IVIG治疗后的临床体征就有明显改善，并且在24个月的随访中仍得以维持。
