弓状体内阿片类物质的作用刺激了依赖生长激素释放因子和蛋白质选择性的进食行为。

Intra-arcuate opiate actions stimulate GRF-dependent and protein-selective feeding.

作者信息

Vaccarino F J, Taube M R

机构信息

Department of Psychology, University of Toronto, Ontario, Canada.

出版信息

Peptides. 1997;18(2):197-205. doi: 10.1016/s0196-9781(96)00283-5.

DOI:10.1016/s0196-9781(96)00283-5

PMID:9149291

Abstract

Growth-hormone releasing factor (GRF) induces feeding and growth hormone (GH) release. Opiates activate GRF neurons regulating GH release. This study sought to determine whether opiate actions on GRF neurons would also stimulate feeding. In Experiment 1, Wistar male rats received intra-arcuate morphine (0, 1, 10, and 20 micrograms/0.5 milligrams) which increased protein intake/feeding activity. In Experiment 2, this effect was blocked when Wistar male rats received intra-SCN/MPOA pretreatments with GRF antiserum followed by intra-arcuate morphine (1 microgram/0.5 milligrams) injections. The data suggest that an opioid trigger may stimulate complementary central (feeding effects) and peripheral (GH release) GRF actions via the arcuate nucleus.

摘要

生长激素释放因子（GRF）可诱导进食和生长激素（GH）释放。阿片类物质激活调节GH释放的GRF神经元。本研究旨在确定阿片类物质对GRF神经元的作用是否也会刺激进食。在实验1中，Wistar雄性大鼠接受弓状核内注射吗啡（0、1、10和20微克/0.5毫克），这增加了蛋白质摄入量/进食活动。在实验2中，当Wistar雄性大鼠接受GRF抗血清的视交叉上核/内侧视前区内预处理，随后进行弓状核内吗啡（1微克/0.5毫克）注射时，这种效应被阻断。数据表明，阿片类触发因素可能通过弓状核刺激互补的中枢（进食效应）和外周（GH释放）GRF作用。