Shiga C, Ohi R, Chiba T, Nio M, Endo N, Mito S, Hino M
Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai, Japan.
Tohoku J Exp Med. 1997 Jan;181(1):217-23. doi: 10.1620/tjem.181.217.
Some patients of biliary atresia (BA) suffer from chronic hepatic dysfunction and/or persistent jaundice. The adverse effects of chronic liver disease on nutrition and growth should be considered on BA patients. We studied 45 BA patients ranging in age from 0.5 to 38 years and divided them into 2 groups. Group A contains the patients whose total bilirubin > or = 2 mg/100 ml, and Group B contains the patients whose total bilirubin < 2 mg/100 ml. We measured height, weight, triceps skin fold (TSF), midarm circumference (MAC) and midarm muscle area (MAMA). Visceral protein kinetics was evaluated on the basis of serum albumin and prealbumin levels. Caloric and protein intake was calculated by collecting intake data for 3 days. The results of this study were; 1) The mean TSF in Group A (47th percentile) was not significantly different from that in Group B (53th percentile). 2) The mean MAMA was significantly lower (p < 0.01) in Group A (16.4th percentile) than in Group B (36.7th percentile) 3) The prealbumin level was significantly lower (p < 0.001) in Group A (mean 9.9 mg/100 ml) than in Group B (mean 18.8 mg/100 ml). The authors conclude that the evaluation of MAMA and prealbumin were very useful to characterize the low metabolic status of protein in the damaged liver. And repeated nutritional assessment was necessary to evaluate liver function and provide adequate nutrition in BA patients.
一些胆道闭锁(BA)患者患有慢性肝功能障碍和/或持续性黄疸。应考虑慢性肝病对BA患者营养和生长的不良影响。我们研究了45例年龄在0.5至38岁之间的BA患者,并将他们分为两组。A组包含总胆红素≥2mg/100ml的患者,B组包含总胆红素<2mg/100ml的患者。我们测量了身高、体重、肱三头肌皮褶厚度(TSF)、上臂围(MAC)和上臂肌肉面积(MAMA)。根据血清白蛋白和前白蛋白水平评估内脏蛋白动力学。通过收集3天的摄入数据计算热量和蛋白质摄入量。本研究结果如下:1)A组的平均TSF(第47百分位数)与B组(第53百分位数)无显著差异。2)A组的平均MAMA(第16.4百分位数)显著低于B组(第36.7百分位数)(p<0.01)。3)A组的前白蛋白水平(平均9.9mg/100ml)显著低于B组(平均18.8mg/100ml)(p<0.001)。作者得出结论,评估MAMA和前白蛋白对于表征受损肝脏中蛋白质的低代谢状态非常有用。并且需要反复进行营养评估以评估BA患者的肝功能并提供充足的营养。