Lescroart O, Roelants I, Cauwenberghs N, De Schrijver R, Kühn E R, Ollevier F
Laboratory of Ecology and Aquaculture, Zoological Institute, Catholic University of Leuven, Belgium.
Life Sci. 1997;60(20):1771-9. doi: 10.1016/s0024-3205(97)00137-9.
Apomorphine is known to stimulate growth hormone release in African catfish following an intraperitoneal (IP) injection. In the present study the effect of apomorphine (5 or 20 mg/kg body weight) on plasma GH levels was evaluated after gastro-intestinal or parenteral delivery. Apomorphine increased the plasma GH concentration regardless of the route of administration, indicating that apomorphine can be absorbed from the intestinal tract. The effect of repeated administration of apomorphine differed clearly between the tested doses. Although a single IP injection with 20 mg apomorphine/kg body weight resulted in a clear increase in plasma GH levels, a second injection given 12 hours later was ineffective. In contrast the last of 4 consecutive injections with 5 mg apomorphine/kg body weight given at intervals of 12 hours stimulated the plasma GH levels in a similar way to a single IP injection with the same dose.
已知阿扑吗啡腹腔注射后可刺激非洲鲶鱼释放生长激素。在本研究中，评估了胃肠给药或非肠道给药后阿扑吗啡（5或20毫克/千克体重）对血浆生长激素水平的影响。无论给药途径如何，阿扑吗啡均能提高血浆生长激素浓度，这表明阿扑吗啡可从肠道吸收。重复给药时，所测试剂量的阿扑吗啡效果明显不同。虽然单次腹腔注射20毫克/千克体重的阿扑吗啡可使血浆生长激素水平明显升高，但12小时后进行的第二次注射则无效。相比之下，以12小时间隔连续4次注射5毫克/千克体重的阿扑吗啡，其最后一次注射刺激血浆生长激素水平的方式与单次腹腔注射相同剂量相似。
