Sugimori T, Griffith D L, Arnaout M A
Department of Medicine, Massachusetts General Hospital, Charlestown, USA.
Kidney Int. 1997 May;51(5):1454-62. doi: 10.1038/ki.1997.199.
Adhesion of cells to each other or to the extracellular matrix provides essential signals that regulate many cellular functions including cell migration, proliferation, differentiation and apoptosis. The integrin superfamily orchestrates many of these complex adhesive events through regulated interactions with a large variety of ligands. Crystallization of some ligands and of a ligand-binding integrin domain, reviewed here, together with extensive mutagenesis studies are beginning to shed light on the inner workings of these receptors.
细胞彼此之间或与细胞外基质的黏附提供了调节许多细胞功能的重要信号，这些功能包括细胞迁移、增殖、分化和凋亡。整合素超家族通过与多种配体的调节性相互作用协调许多此类复杂的黏附事件。本文综述的一些配体和配体结合整合素结构域的结晶，以及广泛的诱变研究，开始揭示这些受体的内部作用机制。
