Sin A, Köse S, Terzioğlu E, Kokuludağ A, Sebik F, Kabakçi T
Department of Immunology, Ege University, Medical Faculty, Izmir, Turkey.
Allergol Immunopathol (Madr). 1997 Mar-Apr;25(2):80-4.
The aim of this study was to determine the prevalence of atopy especially in young aged group in which allergic diseases are frequently seen. We carried out this study in Izmir which is located on the west coast of Turkey and has all the characteristics of mediterranean climate. However, we evaluated whether geographical characteristics such as climate, dampness, kinds of plant might be affected on prevalence of atopy. Participants were randomly selected and detailed standard questionnaire about if they or their relatives had any allergic symptoms were applied. The skin prick tests (SPT) with standardzied allergen extracts were performed and serum total IgE levels were assayed. The study group consisted of 277 individuals, aged 15-25 years. Based on the questionnaire, 123 (44.4%) participants described positive history of atopy. In 127 of 277 subjects (46%) was found at least one positive skin-test response and the most frequent allergen was house-dust mites. SPT was positive in 68 (55.2%) of 123 subjects who had atopic history and in 59 (38%) of 154 subjects who had negative history of atopy. The subjects who had atopic history showed more frequently positive SPT prevalence than the others (p < 0.01). Geometric mean of total IgE level was 105.5 kU/L in SPT positive 127 subjects and 57.7 kU/L in SPT negative 150 subjects. There was a positive relationship between total IgE level and positive SPT (p < 0.01). History of atopy was correlated with total IgE levels in males (p < 0.01) but not in females. Women more often than men reported atopic history in the absence of true atopy.
本研究的目的是确定特应性疾病的患病率，尤其是在经常出现过敏性疾病的年轻人群体中。我们在位于土耳其西海岸、具有地中海气候所有特征的伊兹密尔开展了这项研究。然而，我们评估了气候、湿度、植物种类等地理特征是否可能影响特应性疾病的患病率。参与者是随机选取的，并应用了关于他们或其亲属是否有任何过敏症状的详细标准问卷。采用标准化变应原提取物进行皮肤点刺试验（SPT），并检测血清总IgE水平。研究组由277名年龄在15至25岁之间的个体组成。根据问卷，123名（44.4%）参与者描述有特应性疾病的阳性病史。在277名受试者中的127名（46%）发现至少有一项皮肤试验阳性反应，最常见的变应原是屋尘螨。在有特应性病史的123名受试者中，68名（55.2%）SPT呈阳性，在无特应性病史的154名受试者中，59名（38%）SPT呈阳性。有特应性病史的受试者SPT阳性患病率比其他受试者更频繁（p<0.01）。127名SPT阳性受试者的总IgE水平几何平均值为105.5 kU/L，150名SPT阴性受试者的总IgE水平几何平均值为57.7 kU/L。总IgE水平与SPT阳性之间存在正相关（p<0.01）。特应性病史与男性的总IgE水平相关（p<0.01），但与女性无关。在没有真正特应性疾病的情况下，女性比男性更常报告有特应性病史。
