Park H M, Lambertus J
J Nucl Med. 1977 Nov;18(11):1091-5.
Skeletal and reticuloendothelial images, using Tc-99m HEDP and Tc-99m sulfur colloid respectively, were obtained from two adult patients with osteopetrosis. Skeletal images demonstrated increased activity in multiple fracture sites, in mandibular osteomyelitis, in ends of splayed long bones adjacent to joints, and in the epiphyseal ends of short tubular bones. The remainder of the skeleton involved with osteopetrosis showed no generalized increased uptake of Tc-99m HEDP. These findings indicate that metabolic activity in this disease is abnormally increased in the usual areas of bone growth but appears normal elsewhere. Reticuloendothelial imaging showed an almost total lack of activity in the axial and peripheral skeletal marrow space. Anemia, however, was only moderate in these patients. Skeletal scintigraphy may be useful to evaluate the presence and extent of the frequent complications of osteopetrosis, namely fractures and osteomyelitis.
分别使用锝-99m羟基亚甲基二膦酸盐（Tc-99m HEDP）和锝-99m硫胶体，对两名成年骨硬化症患者进行了骨骼和网状内皮系统显像。骨骼显像显示，多个骨折部位、下颌骨骨髓炎、关节旁增宽长骨的末端以及短管状骨的骨骺端放射性活性增加。其余患有骨硬化症的骨骼部位未显示出Tc-99m HEDP摄取普遍增加。这些发现表明，该疾病的代谢活性在正常骨生长区域异常增加，但在其他部位似乎正常。网状内皮系统显像显示，轴向和外周骨髓腔几乎完全没有放射性活性。然而，这些患者的贫血仅为中度。骨骼闪烁显像可能有助于评估骨硬化症常见并发症（即骨折和骨髓炎）的存在和程度。
