Lingström P, Lundgren F, Birkhed D, Takazoe I, Frostell G
Department of Cariology, Faculty of Odontology, Göteborg University, Sweden.
Eur J Oral Sci. 1997 Apr;105(2):162-9. doi: 10.1111/j.1600-0722.1997.tb00195.x.
The aim was to evaluate the effects of frequent mouthrinses with palatinose, xylitol and a mixture of palatinose and xylitol on plaque pH, plaque formation and cariogenic microorganisms. 15 subjects refrained from toothbrushing during 3 test periods and rinsed 15 x daily for 4 d with 10 ml of: (1) 50% palatinose, (2) 37.5% palatinose + 12.5% xylitol, or (3) 50% xylitol. A contrast period with no mouthrinses was also carried out. The 4 periods were carried out in a randomized order with a cross-over design. After the 4-day periods, 3 parameters were measured: (1) plaque pH during the first 30 min after a mouthrinse with palatinose, a mixture of palatinose and xylitol or xylitol alone, directly followed by a 2nd rinse with 10% sucrose; (2) number of mutans streptococci and lactobacilli in plaque and saliva; (3) plaque index. The most pronounced pH drop for the sugar substitutes was found when rinsing with 50% palatinose after the palatinose period, and the least pH drop with 50% xylitol after the xylitol period. The sucrose rinse gave similar pH fall after all 4 periods. The microbial data showed no differences between the 4 periods, but the mutans streptococcus counts in saliva decreased after the xylitol period in contrast to the 3 other periods. Regarding the plaque index, xylitol gave lower scores compared to the other 3 periods.
目的是评估频繁使用帕拉金糖、木糖醇以及帕拉金糖与木糖醇混合物进行漱口对牙菌斑pH值、牙菌斑形成和致龋微生物的影响。15名受试者在3个测试阶段停止刷牙，每天用10毫升以下溶液漱口15次，持续4天：（1）50%帕拉金糖；（2）37.5%帕拉金糖+12.5%木糖醇；或（3）50%木糖醇。还进行了一个不漱口的对照阶段。这4个阶段采用随机顺序交叉设计。在4天阶段结束后，测量3个参数：（1）用帕拉金糖、帕拉金糖与木糖醇混合物或单独的木糖醇漱口后，紧接着用10%蔗糖再次漱口，在前30分钟内的牙菌斑pH值；（2）牙菌斑和唾液中变形链球菌和乳酸菌的数量；（3）牙菌斑指数。在帕拉金糖阶段后用50%帕拉金糖漱口时，代糖的pH值下降最为明显，而在木糖醇阶段后用50%木糖醇漱口时pH值下降最少。在所有4个阶段后，用蔗糖漱口导致的pH值下降相似。微生物数据显示4个阶段之间没有差异，但与其他3个阶段相比，木糖醇阶段后唾液中的变形链球菌数量减少。关于牙菌斑指数，与其他3个阶段相比，木糖醇的得分更低。
