Jurik A G, Egund N
Department of Diagnostic Radiology R, Aarhus Kommunehospital, Denmark.
Skeletal Radiol. 1997 Apr;26(4):230-8. doi: 10.1007/s002560050227.
To review our experience of chronic recurrent multifocal osteomyelitis (CRMO) and to assess the value of MRI in this rare disease, which mainly affects children and adolescents.
Seventeen patients from our departments were reviewed. All underwent conventional radiography and MRI, and most had bone scintigraphy. All had undergone bone biopsy, with microbiological and histopathological examinations, to exclude infectious disease, tumours and tumour-like lesions.
CRMO affects predominantly the tubular bones of the limbs, followed by the clavicle and the spine. Other locations are rare. Diagnosis is important in avoiding unnecessary diagnostic procedures and to initiate appropriate therapy, and is usually based on a characteristic course and the appearances on radiography. However, CRMO lesions of tubular bones and the spine exhibit quite characteristic MRI features which support the diagnosis, while the appearance of the early clavicular lesion is non-specific. At all sites of CRMO in the skeleton, MRI is valuable in assessing the extent and activity of the lesion. It may exclude pyogenic involvement of the bone and soft tissues and guide effective biopsy.
回顾我们对慢性复发性多灶性骨髓炎（CRMO）的诊疗经验，并评估MRI在这种主要影响儿童和青少年的罕见疾病中的价值。
对我们科室的17例患者进行了回顾性研究。所有患者均接受了传统X线摄影和MRI检查，大多数还进行了骨闪烁显像。所有患者均接受了骨活检，并进行了微生物学和组织病理学检查，以排除感染性疾病、肿瘤及肿瘤样病变。
CRMO主要累及四肢管状骨，其次为锁骨和脊柱。其他部位少见。明确诊断对于避免不必要的诊断程序和启动适当治疗很重要，通常基于特征性病程和X线表现。然而管状骨和脊柱的CRMO病变具有相当特征性的MRI表现，有助于诊断，而早期锁骨病变的表现不具有特异性。在骨骼CRMO的所有部位，MRI对于评估病变范围和活动度均有价值。它可以排除骨和软组织的化脓性病变，并指导有效的活检。
