Waghmode Akshay, Soman Nikhith, Gupta Aryan
Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, IND.
Medical Intern, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, IND.
Cureus. 2022 Jun 27;14(6):e26370. doi: 10.7759/cureus.26370. eCollection 2022 Jun.
Chronic recurrent multifocal osteomyelitis (CRMO) is a rarely reported autoimmune inflammatory condition affecting children and young adults. The typical complaint is recurrent severe bone pain at multiple sites; often imaging suggests features of osteomyelitis or malignancy. However, the biopsy is always negative for any growth in culture and histopathology detects only inflammatory cells. This is a diagnosis of exclusion with various diagnostic criteria. We had a 20-year-old male presenting with recurring pain and swelling in the right hand and left foot for more than seven months. Imaging revealed bone marrow edema with the expansion of bone and sclerosis involving the third metacarpal of the right hand and first metatarsal of the left foot. Acute phase reactants were mildly raised with biopsy showing inflammatory cells. However, the cultures grown from the lesion were sterile. After comparing it with the various diagnostic criteria, a diagnosis of CRMO was made.
慢性复发性多灶性骨髓炎（CRMO）是一种罕见的自身免疫性炎症性疾病，影响儿童和年轻人。典型症状是多个部位反复出现严重骨痛；影像学检查常提示骨髓炎或恶性肿瘤的特征。然而，活检培养始终未发现任何生长物，组织病理学检查仅发现炎性细胞。这是一种需依据多种诊断标准进行排除的诊断。我们有一名20岁男性，右手和左脚反复疼痛肿胀超过7个月。影像学检查显示骨髓水肿，伴有骨质膨胀和硬化，累及右手第三掌骨和左脚第一跖骨。急性期反应物轻度升高，活检显示炎性细胞。然而，病变部位培养无菌。与各种诊断标准进行比较后，诊断为CRMO。
