Hasan S A, Baker R S, Sun W S, Rouholiman B R, Chuke J C, Cowen D E, Porter J D
Department of Ophthalmology, University of Kentucky Medical Center, Lexington, USA.
Arch Ophthalmol. 1997 May;115(5):631-6. doi: 10.1001/archopht.1997.01100150633010.
To investigate eyelid movements in patients with benign essential blepharospasm (BEB), with an emphasis on the characterization of the kinematics of normal and spastic blinks, assessment of interocular differences, and further delineation of the role of adaptive blink mechanisms in eyelid movement disorders.
The electromagnetic search coil technique was used to record the metrics of blinks bilaterally in 5 patients with untreated BEB. Eyelid kinematics and the main-sequence (peak velocity vs amplitude) relationships were analyzed.
Patients with BEB exhibited a decrease in blink amplitude and peak velocity. Moreover, the main-sequence slope was decreased bilaterally. Spasms were bilateral and relatively conjugate. There was no change in the coordination of normal blinking across the 2 eyelids.
These data demonstrate the operation of the adaptive regulation of blinking in an eyelid movement disorder. The findings suggest that the adaptive regulation of blink is a bilateral event. Blink-adaptive control systems can act on the blink reflex excitability and main-sequence relationships, changing these either together or independently. The hyperexcitable blink reflex of BEB is met by what is believed to be an adaptive decrease in the main-sequence slope that would decrease the strength of debilitating spasms. Collectively, these data extend the knowledge of the pathophysiology of BEB and, perhaps more important, establish the role of blink system plasticity in eyelid movement disorders.
研究良性特发性眼睑痉挛（BEB）患者的眼睑运动，重点是正常眨眼和痉挛性眨眼的运动学特征、双眼差异评估以及进一步阐明适应性眨眼机制在眼睑运动障碍中的作用。
采用电磁搜索线圈技术对5例未经治疗的BEB患者双侧眨眼指标进行记录。分析眼睑运动学和主序列（峰值速度与幅度）关系。
BEB患者眨眼幅度和峰值速度降低。此外，双侧主序列斜率降低。痉挛为双侧性且相对共轭。双眼正常眨眼的协调性无变化。
这些数据证明了在眼睑运动障碍中眨眼适应性调节的作用。研究结果表明眨眼的适应性调节是双侧性事件。眨眼适应性控制系统可作用于眨眼反射兴奋性和主序列关系，使其同时或独立改变。BEB的眨眼反射过度兴奋通过主序列斜率的适应性降低来应对，这会降低衰弱性痉挛的强度。总体而言，这些数据扩展了对BEB病理生理学的认识，也许更重要的是，确立了眨眼系统可塑性在眼睑运动障碍中的作用。
