Porter J D, Baker R S, Stava M W, Gaddie I B, Brueckner J K
Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536-0084.
Exp Brain Res. 1993;96(1):77-82. doi: 10.1007/BF00230440.
The alterations induced in eyelid movement metrics subsequent to unilateral injections of botulinum toxin type A into the orbicularis oculi muscle were studied in chronic alert monkeys using the search coil technique. Botulinum toxin caused rapid paralysis of blinks in the treated eyelid. The amplitude and peak velocity of blinks generated by this eyelid remained at or below 20% of that of the fellow, untreated eyelid for 10-20 days. Blink amplitude gain increased linearly thereafter, attaining control values by 40-60 days after injection. Recovery of blink peak velocity was slower. The adaptive alterations in blink duration that were observed during the acute phase of toxin paralysis suggest that the mechanisms responsible for blink reflex plasticity may produce bilateral adjustments in eyelid function. Taken together, these data establish a quantitative data base that can be exploited in order to: (1) better understand the neural adaptive mechanisms that operate during eyelid movements and (2) allow quantitative comparisons between current treatment protocols that employ botulinum toxin and protocols that may lead to improvements in the treatment of chronic eyelid spasm (blepharospasm).
运用搜索线圈技术，在慢性清醒的猴子身上研究了向眼轮匝肌单侧注射A型肉毒杆菌毒素后眼睑运动指标的变化。肉毒杆菌毒素导致注射侧眼睑快速出现眨眼麻痹。该眼睑产生的眨眼幅度和峰值速度在10 - 20天内保持在或低于未治疗的对侧眼睑的20%。此后眨眼幅度增益呈线性增加，在注射后40 - 60天达到对照值。眨眼峰值速度的恢复较慢。在毒素麻痹急性期观察到的眨眼持续时间的适应性变化表明，负责眨眼反射可塑性的机制可能会对眼睑功能产生双侧调节。综上所述，这些数据建立了一个定量数据库，可用于：（1）更好地理解眼睑运动过程中起作用的神经适应性机制；（2）对当前使用肉毒杆菌毒素的治疗方案与可能改善慢性眼睑痉挛（睑痉挛）治疗的方案进行定量比较。
