Hull P R
Department of Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
Dermatology. 1997;194 Suppl 1:7-9. doi: 10.1159/000246174.
The treatment of onychomycosis has improved considerably following the introduction of the oral antifungals terbinafine and itraconazole. The pharmacokinetic characteristics of both these drugs has made short treatment times effective. Patients with a culture-proven dermatophyte infection of the toe-nails, receiving terbinafine 250 mg daily for 12 weeks, have a 70% chance of cure. The risk of relapse is probably less than 10%, and this may be prevented by a further course of terbinafine should the expected increasing length of unaffected nail growth stall or cultures become positive. Once cured, the regular and prophylactic use of an effective topical antifungal may help to prevent a recurrence of tinea pedis and onychomycosis.
口服抗真菌药特比萘芬和伊曲康唑的引入，使甲癣的治疗有了显著改善。这两种药物的药代动力学特性使得短疗程治疗有效。经培养证实为趾甲皮肤癣菌感染的患者，每日服用250mg特比萘芬，持续12周，治愈几率为70%。复发风险可能低于10%，如果预期未受影响的指甲生长停滞或培养结果呈阳性，再次服用特比萘芬疗程可能会预防复发。一旦治愈，定期预防性使用有效的外用抗真菌药可能有助于预防足癣和甲癣复发。
