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本文引用的文献

1
An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors.一种缺乏DNA结合结构域并与其他受体形成异二聚体的孤儿核激素受体。
Science. 1996 May 31;272(5266):1336-9. doi: 10.1126/science.272.5266.1336.
2
MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation.MafB是Ets-1的相互作用伙伴和阻遏物，可抑制红细胞分化。
Cell. 1996 Apr 5;85(1):49-60. doi: 10.1016/s0092-8674(00)81081-8.
3
Finding prospective partners in the library: the two-hybrid system and phage display find a match.在文库中寻找潜在伴侣：双杂交系统与噬菌体展示找到匹配对象。
Trends Biochem Sci. 1995 Dec;20(12):511-6. doi: 10.1016/s0968-0004(00)89119-7.
4
B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.
Oncogene. 1995 Dec 7;11(11):2255-65.
5
The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities.作为转录调节因子的干扰素诱导型p202蛋白：对核因子-κB、c-Fos和c-Jun活性的抑制作用
Mol Cell Biol. 1996 Jan;16(1):359-68. doi: 10.1128/MCB.16.1.359.
6
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.鸟嘌呤核苷酸释放因子hSos1与Grb2结合，并将受体酪氨酸激酶与Ras信号传导联系起来。
Nature. 1993 May 6;363(6424):85-8. doi: 10.1038/363085a0.
7
Suppression of oncogene-induced transformation by a deletion mutant of c-jun.c-jun缺失突变体对癌基因诱导的转化的抑制作用
Oncogene. 1993 Apr;8(4):877-86.
8
Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.Mad：一种与Max形成异二聚体的伙伴，可拮抗Myc转录活性。
Cell. 1993 Jan 29;72(2):211-22. doi: 10.1016/0092-8674(93)90661-9.
9
Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domain.maf癌基因家族的两个新成员mafK和mafF编码缺乏假定反式激活结构域的核b-Zip蛋白。
Oncogene. 1993 Sep;8(9):2371-80.
10
A Jun-binding protein related to a putative tumor suppressor.一种与假定肿瘤抑制因子相关的Jun结合蛋白。
Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6726-30. doi: 10.1073/pnas.90.14.6726.

通过一种检测蛋白质-蛋白质相互作用的新方法分离出一种AP-1阻遏物。

Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.

作者信息

Aronheim A, Zandi E, Hennemann H, Elledge S J, Karin M

机构信息

Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California, San Diego, La Jolla 92093-0636, USA.

出版信息

Mol Cell Biol. 1997 Jun;17(6):3094-102. doi: 10.1128/MCB.17.6.3094.

DOI:10.1128/MCB.17.6.3094
PMID:9154808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC232162/
Abstract

Transcription factor AP-1 transduces environmental signals to the transcriptional machinery. To ensure a quick response yet maintain tight control over AP-1 target genes, AP-1 activity is likely to be negatively regulated in nonstimulated cells. To identify proteins that interact with the Jun subunits of AP-1 and repress its activity, we developed a novel screen for detecting protein-protein interactions that is not based on a transcriptional readout. In this system, the mammalian guanyl nucleotide exchange factor (GEF) Sos is recruited to the Saccharomyces cerevisiae plasma membrane harboring a temperature-sensitive Ras GEF, Cdc25-2, allowing growth at the nonpermissive temperature. Using the Sos recruitment system, we identified new c-Jun-interacting proteins. One of these, JDP2, heterodimerizes with c-Jun in nonstimulated cells and represses AP-1-mediated activation.

摘要

转录因子AP-1将环境信号传导至转录机制。为确保快速响应并对AP-1靶基因保持严格控制，在未受刺激的细胞中，AP-1的活性可能受到负调控。为了鉴定与AP-1的Jun亚基相互作用并抑制其活性的蛋白质，我们开发了一种新型筛选方法来检测蛋白质-蛋白质相互作用，该方法不基于转录读数。在这个系统中，哺乳动物鸟苷酸交换因子（GEF）Sos被招募到含有温度敏感型Ras GEF（Cdc25-2）的酿酒酵母质膜上，从而使其在非允许温度下生长。利用Sos招募系统，我们鉴定出了新的与c-Jun相互作用的蛋白质。其中之一JDP2，在未受刺激的细胞中与c-Jun形成异源二聚体并抑制AP-1介导的激活。