日本同胞中FcεRIβ基因座特应性的母系遗传。

Maternal inheritance of atopy at the Fc epsilon RI beta locus in Japanese sibs.

作者信息

Mao X O, Shirakawa T, Sasaki S, Enomoto T, Morimoto K, Hopkin J M

机构信息

Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, Suita, Japan.

出版信息

Hum Hered. 1997 May-Jun;47(3):178-80. doi: 10.1159/000154409.

DOI:10.1159/000154409

PMID:9156331

Abstract

Twenty-four Japanese atopic sibs with asthma and/or rhinitis were tested for polymorphic microsatellite repeats of Fc epsilon RI beta on chromosome 11q13. Significantly increased sharing of maternal alleles was found chi 2 = 5.86, p < 0.025) while no significant sharing was found for paternal alleles. These findings confirm maternal inheritance of atopy at this locus in a non-Caucasian population.

摘要

对24名患有哮喘和/或鼻炎的日本特应性同胞进行了11q13染色体上FcεRIβ多态微卫星重复序列检测。发现母系等位基因共享显著增加（χ2 = 5.86，p < 0.025），而父系等位基因未发现显著共享。这些发现证实了在非白种人群体中该位点特应性的母系遗传。