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用于中子俘获治疗的毛细管光学器件。

Capillary optics for neutron capture therapy.

作者信息

Peurrung A J

机构信息

Pacific Northwest Laboratory, Richland, Washington 99352, USA.

出版信息

Med Phys. 1996 Apr;23(4):487-94. doi: 10.1118/1.597680.

Abstract

The development of capillary neutron optics permits a new technology for neutron capture therapy involving the application of a focused thermal neutron beam at the medically optimal location within the patient. A subthermal neutron beam begins to converge as it travels through a neutron "lens," reaching a narrow focus within a tube that allows it to pass directly to the treatment region. This technique results in a substantially lower dose to untreated parts of the patient and a substantially weaker radiation field in the treatment room generally. Additional advantages include the relative ease of thermal neutron generation and the ability to shield the patient completely and effectively from fast neutrons or gamma rays originating at the neutron source. This work describes the application of capillary optics to neutron capture therapy, along with Monte Carlo calculations of the neutron flux profiles within a patient for an optimized system design. Specific dose profiles for the case of boron neutron capture therapy within the brain are also provided.

摘要

毛细管中子光学的发展为中子俘获治疗带来了一项新技术,该技术涉及在患者体内医学上的最佳位置应用聚焦热中子束。亚热中子束在穿过中子“透镜”时开始汇聚,在一根管子内达到狭窄的焦点,使其能够直接传递到治疗区域。这种技术可使患者未治疗部位所受剂量大幅降低,并且通常会使治疗室内的辐射场显著减弱。其他优点还包括热中子产生相对容易,以及能够完全有效地为患者屏蔽源自中子源的快中子或伽马射线。这项工作描述了毛细管光学在中子俘获治疗中的应用,以及针对优化系统设计对患者体内中子通量分布进行的蒙特卡罗计算。还提供了脑部硼中子俘获治疗情况下的特定剂量分布。

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