Shah R C, Raman P V, Sheth P V
J Pharm Sci. 1977 Nov;66(11):1551-2. doi: 10.1002/jps.2600661112.
Polyethylene glycol 6000 was evaluated as a binder for the direct compression of 11 tablet formulations. Six formulations compressed quite well, and the resulting tablets were satisfactory in all respects. To evaluate stability, actual shelflife studies were considered more appropriate than the accelerated studies. After a shelflife of 3 years, five of the six formulations were stable. The ascorbic acid formulation was stable for up to 18 months.
对聚乙二醇6000作为11种片剂配方直接压片的黏合剂进行了评估。六种配方压片效果相当好，所得片剂在各方面均令人满意。为评估稳定性，实际保质期研究被认为比加速试验更合适。经过3年的保质期后，六种配方中的五种保持稳定。抗坏血酸配方稳定期长达18个月。
