聚电解质对药物转运的影响II：渗透作用
Effects of polyelectrolytes on drug transport II: permeation.
作者信息
Farng K F, Nelson K G
出版信息
J Pharm Sci. 1977 Nov;66(11):1611-4. doi: 10.1002/jps.2600661127.
PMID:915739
Abstract
The permeation rate of salicylate across a dialysis membrane was studied in the presence of various types of carboxymethylcellulose. The presence of the polymer in the salicylate solution increased the permeation rate of salicylate. The data were analyzed with a diffusional model in which the viscosity and charge effects were evaluated separately.
摘要
在各种类型的羧甲基纤维素存在的情况下，研究了水杨酸盐在透析膜上的渗透速率。水杨酸盐溶液中聚合物的存在提高了水杨酸盐的渗透速率。使用扩散模型对数据进行分析，在该模型中分别评估了粘度和电荷效应。
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