Nomura T
Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Japan.
Math Biosci. 1997 Jun;142(2):79-89. doi: 10.1016/s0025-5564(97)00010-2.
The problem of selection in the prediction of effective population size for a sex-linked locus was addressed in terms of the cumulative effect of selection on change in frequency of a sex-linked neutral gene. To express the cumulative effect of selection, a transition matrix approach was used. It was found that the terms accounting for the cumulative change in gene frequency show different expressions, depending on the gametic pathways. This dependency is due to the fact that the heterogametic sex transmits a sex-linked gene only to offspring of the homogametic sex, whereas the homogametic sex transmits to offspring of both sexes. Monte Carlo simulation was carried out to check the obtained prediction equation. The result showed that there is a good agreement between observed and predicted effective sizes.
针对性连锁基因座有效种群大小预测中的选择问题，从选择对性连锁中性基因频率变化的累积效应方面进行了探讨。为了表达选择的累积效应，采用了转移矩阵方法。结果发现，考虑基因频率累积变化的项根据配子途径表现出不同的表达式。这种依赖性是由于异配性别仅将性连锁基因传递给同配性别的后代，而同配性别则传递给两性的后代。进行了蒙特卡罗模拟以检验所得到的预测方程。结果表明，观察到的和预测的有效大小之间有很好的一致性。
