核组织与基因表达：同源配对和长程相互作用。
Nuclear organization and gene expression: homologous pairing and long-range interactions.
作者信息
Henikoff S
机构信息
Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
出版信息
Curr Opin Cell Biol. 1997 Jun;9(3):388-95. doi: 10.1016/s0955-0674(97)80012-9.
PMID:9159074
Abstract
Genetic studies have demonstrated that pairing interactions between homologous chromosomes and long-range associations between nonhomologous sites can influence gene expression. Recent work has revealed that such influences are widespread in eukaryotes and that chromosome architecture is likely to be of fundamental importance for nuclear structure and function.
摘要
遗传学研究表明，同源染色体之间的配对相互作用以及非同源位点之间的长程关联能够影响基因表达。最近的研究揭示，这种影响在真核生物中广泛存在，并且染色体结构可能对于细胞核的结构和功能至关重要。
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