Jallepalli P V, Kelly T J
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 N Wolfe Street, 601 Pre-Clinical Teaching Building, Baltimore, MD 21205, USA.
Curr Opin Cell Biol. 1997 Jun;9(3):358-63. doi: 10.1016/s0955-0674(97)80008-7.
A growing body of evidence indicates that cyclin-dependent kinases (CDKs) regulate the activity of eukaryotic origins of replication both positively and negatively. Although the details of this control remain unclear, recent work suggests that CDKs act directly at origins, where they associate with and phosphorylate several key initiator proteins. These data suggest that a CDK-regulated replication switch operates at each origin to ensure that initiation occurs precisely once per cell cycle.
越来越多的证据表明，细胞周期蛋白依赖性激酶（CDK）对真核生物复制起点的活性具有正向和负向调节作用。尽管这种调控的具体细节尚不清楚，但最近的研究表明，CDK直接作用于复制起点，在那里它们与几种关键的起始蛋白结合并使其磷酸化。这些数据表明，一个由CDK调控的复制开关在每个复制起点起作用，以确保每个细胞周期精确地起始一次。
