Keller W, Minvielle-Sebastia L
Department of Cell Biology, Biozentrum University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland.
Curr Opin Cell Biol. 1997 Jun;9(3):329-36. doi: 10.1016/s0955-0674(97)80004-x.
Many components of the mammalian and yeast pre-mRNA 3'-end-processing machinery have recently been purified and cDNAs or genes coding for these factors have been cloned. Most of the factors consist of multiple subunits, some of which serve to bind the RNA substrate, others of which are involved in forming a complex network of protein-protein interactions. Most of the mammalian 3'-end-processing factors are similar in their amino acid sequence to the yeast factors, indicating that they have a common evolutionary history.
哺乳动物和酵母前体mRNA 3'末端加工机制的许多组分最近已被纯化，编码这些因子的cDNA或基因也已被克隆。大多数因子由多个亚基组成，其中一些亚基用于结合RNA底物，其他亚基则参与形成蛋白质-蛋白质相互作用的复杂网络。大多数哺乳动物3'末端加工因子的氨基酸序列与酵母因子相似，这表明它们有共同的进化史。
