Valente E J, Lingafelter E C, Porter W R, Trager W F
J Med Chem. 1977 Nov;20(11):1489-93. doi: 10.1021/jm00221a025.
Warfarin in solution is shown to consist of three interconverting tautomeric structures, two of which are cyclic diastereomeric hemiketals, while the third and minor component is the open-chain intermediate form. The configurations of all the tautomers as well as the major conformations of the cyclic tautomers are assigned. The assignments are supported by comparison with the chemical shift and coupling constant parameters of structurally fixed model compounds.
溶液中的华法林由三种相互转化的互变异构体结构组成，其中两种是环状非对映异构半缩酮，而第三种也是含量较少的成分是开链中间体形式。确定了所有互变异构体的构型以及环状互变异构体的主要构象。通过与结构固定的模型化合物的化学位移和耦合常数参数进行比较，证实了这些确定结果。
