二苯并[b,e]氧杂环庚烷烷酸类作为非甾体抗炎药。3. ω-(6,11-二氢-11-氧代二苯并[b,e]氧杂环庚烷-2-基)烷酸。
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)alkanoic acids.
作者信息
Aultz D E, McFadden A R, Lassman H B
出版信息
J Med Chem. 1977 Nov;20(11):1499-501. doi: 10.1021/jm00221a028.
PMID:915913
Abstract
Omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric, -hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times more potent than the octanoic analogue, and 0.43 times as potent as indomethacin.
摘要
在角叉菜胶致爪肿胀试验中评估了ω-(6,11-二氢-11-氧代二苯并[b,e]氧杂环庚三烯-2-基)丁酸、己酸和辛酸。活性最强的化合物，即丁酸类似物，其效力比己酸化合物高1.80倍，比辛酸类似物高1.15倍，是吲哚美辛效力的0.43倍。
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