资源竞争作为B细胞稳态的一种机制。
Resource competition as a mechanism for B cell homeostasis.
作者信息
McLean A R, Rosado M M, Agenes F, Vasconcellos R, Freitas A A
机构信息
Laboratoire des Dynamiques Lymphocytaires, Institut Pasteur, F-75724 Paris Cedex 15, France.
出版信息
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5792-7. doi: 10.1073/pnas.94.11.5792.
Abstract
Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M. C. (1992) Nature (London) 356, 397-400]. We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers. We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.
摘要
细胞对生存信号的竞争为维持细胞内稳态提供了一个有说服力且引人注目的机制[拉夫，M.C.（1992年）《自然》（伦敦）356卷，397 - 400页]。我们对资源竞争在调节外周B细胞数量中的作用进行了理论和实验研究。我们运用形式生态学竞争理论、种间竞争的数学模型以及竞争性再增殖实验，以表明B细胞必须通过竞争才能在外周持续存在，并且抗原构成了B细胞竞争的部分资源。
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