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磁共振成像对远离缺血的继发性改变的检测：大鼠大脑中动脉闭塞后的初步观察

MR detection of secondary changes remote from ischemia: preliminary observations after occlusion of the middle cerebral artery in rats.

作者信息

Nakane M, Tamura A, Nagaoka T, Hirakawa K

机构信息

Department of Neurosurgery, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

出版信息

AJNR Am J Neuroradiol. 1997 May;18(5):945-50.

PMID:9159375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8338101/
Abstract

PURPOSE

To determine whether secondary MR changes occur in the thalamus or the substantia nigra after middle cerebral artery (MCA) occlusion in rats.

METHODS

Sprague-Dawley rats were subjected to MCA occlusion. At varying intervals, proton density-, T1-, and T2-weighted images were obtained with a 4.7-T superconductive MR unit.

RESULTS

T2-weighted images revealed an area of high signal intensity in the ipsilateral substantia nigra 4 days after occlusion. A lesion of low signal intensity appeared in the ipsilateral thalamus 7 days after surgery on proton density- and/or T2-weighted images.

CONCLUSION

MR showed secondary changes in the thalamus and the substantia nigra after MCA occlusion in rats. MR imaging should provide more information on the neuropathology of the delayed neuronal degeneration after cerebral ischemia.

摘要

目的

确定大鼠大脑中动脉（MCA）闭塞后丘脑或黑质是否会出现继发性磁共振（MR）改变。

方法

对Sprague-Dawley大鼠进行MCA闭塞。在不同时间间隔，使用4.7-T超导MR设备获取质子密度加权、T1加权和T2加权图像。

结果

T2加权图像显示闭塞后4天同侧黑质出现高信号强度区域。术后7天，质子密度加权和/或T2加权图像显示同侧丘脑出现低信号强度病变。

结论

MR显示大鼠MCA闭塞后丘脑和黑质出现继发性改变。MR成像应为脑缺血后延迟性神经元变性的神经病理学提供更多信息。