Lennard-Jones J E, Shivananda S
Department of Gastroenterology, St Mark's Hospital, Harrow, UK.
Eur J Gastroenterol Hepatol. 1997 Apr;9(4):353-9. doi: 10.1097/00042737-199704000-00007.
To compare the methods used for diagnosis and the clinical features of non-specific inflammatory bowel disease (IBD) in the north and south of Europe.
A prospective study over 2 years in 1991-3 at eight centres in the north and 12 in the south of Europe using the same criteria for disease definition and same protocol for recording data.
Specialist gastroenterological centres with good diagnostic facilities at which every effort was made to ascertain all new cases of IBD seen in other departments and primary care in a defined geographical area of known population.
A total of 2201 patients newly diagnosed as suffering from IBD, 1397 with ulcerative colitis (UC), 706 with Crohn's disease (CD) and 116 with indeterminate colitis (IND).
Diagnostic methods used were similar in north and south, a biopsy or resection specimen was available for examination in 94 and 95%, of cases of UC and 92 and 87% of CD in north and south, respectively. The type, clinical presentation, site and extent of disease were similar in north and south. Treatment followed a common pattern and mortality from IBD was low in the first year after diagnosis. In both areas, age of onset of UC tended to be later than CD.
The standard of diagnosis and clinical features of IBD are similar in specialist centres throughout Europe so providing a valid basis for this aspect of collaborative epidemiological or other studies.
比较欧洲南北部非特异性炎性肠病（IBD）的诊断方法及临床特征。
1991年至1993年在欧洲北部的8个中心和南部的12个中心进行了一项为期2年的前瞻性研究，采用相同的疾病定义标准和相同的数据记录方案。
拥有良好诊断设施的专科胃肠病中心，在已知人口的特定地理区域内，尽一切努力确定在其他科室和初级保健机构中见到的所有IBD新病例。
共有2201例新诊断为IBD的患者，其中1397例为溃疡性结肠炎（UC），706例为克罗恩病（CD），116例为不确定性结肠炎（IND）。
欧洲南北部使用的诊断方法相似，北部和南部UC病例分别有94%和95%、CD病例分别有92%和87%可获得活检或切除标本以供检查。疾病的类型、临床表现、部位和范围在南北部相似。治疗遵循共同模式，IBD诊断后第一年的死亡率较低。在两个地区，UC的发病年龄往往比CD晚。
欧洲各专科中心IBD的诊断标准和临床特征相似，为协作性流行病学研究或其他研究的这一方面提供了有效依据。
