Wagner G J, Rabkin J G, Rabkin R
Department of Psychiatry, New York Psychiatric Institute, New York 10032, USA.
J Psychosom Res. 1997 Apr;42(4):407-11. doi: 10.1016/s0022-3999(96)00366-2.
This report documents findings from an open trial of dextroamphetamine in the treatment of depression and low energy in AIDS patients. Dextroamphetamine offers the potential for rapid onset of effect and activation properties, both of which are important to persons with late stage HIV illness. Primary inclusion criteria included having a DSM-III-R depressive disorder, debilitating low energy, CD4 cell count below 200 cells/mm3, and no history of drug dependence. The trial consisted of open treatment in a 6-week protocol, with indefinite follow-up. Twenty-four men entered the study, 18 of 19 (95%) patients who completed at least 6 weeks of treatment reported substantial improvement with regard to both mood and energy at a median dosage of 10 mg/day. These results suggest that dextroamphetamine is a potentially effective, fast acting antidepressant treatment for this population and call for a larger, controlled trial.
本报告记录了右旋苯丙胺治疗艾滋病患者抑郁症和精力不足的开放试验结果。右旋苯丙胺具有起效迅速和激活特性的潜力，这对晚期艾滋病毒感染者都很重要。主要纳入标准包括患有DSM-III-R抑郁症、使人衰弱的精力不足、CD4细胞计数低于200个细胞/mm3且无药物依赖史。该试验包括按照6周方案进行开放治疗，并进行无限期随访。24名男性进入研究，19名患者中有18名（95%）完成了至少6周的治疗，报告称在中位剂量为10毫克/天的情况下，情绪和精力均有显著改善。这些结果表明，右旋苯丙胺对该人群可能是一种有效的快速抗抑郁治疗方法，并呼吁进行更大规模的对照试验。
