Rodríguez L, Sánchez R, Hernández J, Carrillo L, Oliva J, Heredero L
Genetic Department, Gynaecological and Obstetrics Hospital Ramon Gonzalez Coro, Havana City, Cuba.
Prenat Diagn. 1997 Apr;17(4):301-4. doi: 10.1002/(sici)1097-0223(199704)17:4<301::aid-pd969>3.0.co;2-x.
Progressively since 1982 and as part of a nationwide programme for the diagnosis and prevention of genetic diseases, maternal serum alpha-fetoprotein (MS-AFP) screening and ultrasound fetal monitoring has been implemented in all pregnant women in Cuba. In Havana City, 328,983 pregnant women underwent MS-AFP screening between 15 and 19 weeks of gestational age. With a cut-off level of > or = 2 multiples of the normal median (MOM), 1767 amniocenteses were carried out to determine the levels of amniotic fluid AFP and 685 malformed fetuses were diagnosed. By ultrasound fetal monitoring, an additional 686 malformed fetuses were detected. As a result of the programme, the birth prevalence of neural tube defects has fallen by 90 per cent.
自1982年起，并作为全国性遗传病诊断和预防计划的一部分，古巴对所有孕妇实施了母血清甲胎蛋白（MS-AFP）筛查和超声胎儿监测。在哈瓦那市，328983名孕妇在孕15至19周时接受了MS-AFP筛查。以正常中位数的2倍或更高倍数（MOM）为临界值，进行了1767次羊膜穿刺术以测定羊水甲胎蛋白水平，并诊断出685例畸形胎儿。通过超声胎儿监测，又检测出686例畸形胎儿。由于该计划的实施，神经管缺陷的出生患病率下降了90%。
