Rodriguez P L, Heredero B, Oliva R J, Zaldivar G O
Genetics Department, Gyneco-Obstetrics Hospital, Ramon Gonzalez Coro, Havana, Cuba.
Prenat Diagn. 1987 Nov;7(9):657-61. doi: 10.1002/pd.1970070908.
Prenatal screening was carried out in Havana City, Cuba, as part of a National Medical Genetics Programme, in order to detect elevated alpha-fetoprotein concentration in maternal serum (MS-AFP). A total of 97,900 pregnant women between 15 and 19 weeks of pregnancy were tested from 1982 to 1985. A double-antibody-sandwich technique was used. 173 malformed fetuses were detected. Confirmation was by ultrasonography, elevated AFP values in a second serum sample and in amniotic fluid and acetylcholinesterase. No termination of a normal pregnancy occurred. The screening of all pregnancies is easy, economical and useful for detecting not only fetuses suffering from open Neural Tube Defects (NTDs) and other severe disorders but also pregnancies at risk of further complications.
作为国家医学遗传学项目的一部分，古巴哈瓦那市开展了产前筛查，以检测孕妇血清中甲胎蛋白（MS-AFP）浓度升高的情况。1982年至1985年期间，共对97900名怀孕15至19周的孕妇进行了检测。采用了双抗体夹心技术。检测出173例畸形胎儿。通过超声检查、第二份血清样本和羊水以及乙酰胆碱酯酶中甲胎蛋白值升高进行确诊。未出现正常妊娠终止的情况。对所有妊娠进行筛查简便、经济且有用，不仅有助于检测患有开放性神经管缺陷（NTDs）和其他严重疾病的胎儿，还能检测有进一步并发症风险的妊娠。
