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竞争风险研究中累积发病率函数的非参数推断。

Non-parametric inference for cumulative incidence functions in competing risks studies.

作者信息

Lin D Y

机构信息

Department of Biostatistics, University of Washington, Seattle 98195, USA.

出版信息

Stat Med. 1997 Apr 30;16(8):901-10. doi: 10.1002/(sici)1097-0258(19970430)16:8<901::aid-sim543>3.0.co;2-m.

Abstract

In the competing risks problem, a useful quantity is the cumulative incidence function, which is the probability of occurrence by time t for a particular type of failure in the presence of other risks. The estimator of this function as given by Kalbfleisch and Prentice is consistent, and, properly normalized, converges weakly to a zero-mean Gaussian process with a covariance function for which a consistent estimator is provided. A resampling technique is developed to approximate the distribution of this process, which enables one to construct confidence bands for the cumulative incidence curve over the entire time span of interest and to perform Kolmogorov-Smirnov type tests for comparing two such curves. An AIDS example is provided.

摘要

在竞争风险问题中,一个有用的量是累积发病率函数,它表示在存在其他风险的情况下,特定类型的失败在时间t发生的概率。卡尔弗莱什(Kalbfleisch)和普伦蒂斯(Prentice)给出的该函数的估计量是一致的,并且经过适当归一化后,弱收敛到一个零均值高斯过程,该过程具有一个协方差函数,对此提供了一个一致估计量。开发了一种重采样技术来近似该过程的分布,这使得人们能够在整个感兴趣的时间跨度内为累积发病率曲线构建置信带,并进行柯尔莫哥洛夫-斯米尔诺夫(Kolmogorov-Smirnov)类型的检验以比较两条这样的曲线。文中给出了一个艾滋病的例子。

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