Schino G, Perretta G, Taglioni A M, Monaco V, Troisi A
Dipartimento di Genetica e Biologia Molecolare, Università di Roma La Sapienza, Italy.
Anxiety. 1996;2(4):186-91. doi: 10.1002/(SICI)1522-7154(1996)2:4<186::AID-ANXI5>3.0.CO;2-M.
Using a within-subject cross-over, vehicle-controlled design, we investigated the acute effects of benzodiazepine receptor ligands with different mechanisms of action on the displacement activities (scratching, self-grooming, and body shake) of seven male macaques living in social groups. Our aim was to test the discriminative validity of displacement activities as an ethopharmacological model of anxiety. Subjects were given i.m. lorazepam (0.10, 0.20, 0.25 mg/ kg) and FG 7142 (0.1, 0.3, 1.0 mg/kg). The frequency of displacement activities was decreased by the anxiolytic lorazepam and increased by the anxiogenic FG 7142 in a dose-dependent manner. Displacement activities were apparently more sensitive to anxiolytic treatment than other behavior patterns indicative of an anxiety state (i.e., visual scanning of the social environment and fear responses directed to dominant males). These results suggest that primate displacement activities are a valid ethopharmacological model of anxiety.
采用受试者内交叉、 vehicle对照设计，我们研究了具有不同作用机制的苯二氮䓬受体配体对7只生活在社会群体中的雄性猕猴的替代活动（抓挠、自我梳理和身体抖动）的急性影响。我们的目的是测试替代活动作为焦虑的行为药理学模型的判别效度。给受试者肌肉注射劳拉西泮（0.10、0.20、0.25mg/kg）和FG 7142（0.1、0.3、1.0mg/kg）。替代活动的频率在抗焦虑药物劳拉西泮作用下降低，而在致焦虑药物FG 7142作用下以剂量依赖方式增加。替代活动对抗焦虑治疗似乎比其他指示焦虑状态的行为模式（即对社会环境的视觉扫描和对占主导地位雄性的恐惧反应）更敏感。这些结果表明，灵长类动物的替代活动是一种有效的焦虑行为药理学模型。
