Yamazaki K, Katoh H, Yamamoto N, Kurihara K, Kuwabara M, Kodama M, Kawaguchi A, Funami Y, Wakabayashi T
Tsukuba Research Laboratories, Eisai Co., Ltd., Tokodai, Ibaraki, Japan.
Am J Hypertens. 1997 May;10(5 Pt 2):94S-97S.
Dahl-Iwai salt-sensitive (S) and salt-resistant (R) rat strains were established as inbred strains at Brookhaven National Laboratory, NY, and were introduced into Eisai Co., Ltd., Japan, and designated DIS/Eis and DIR/Eis. To examine whether there are different allele distributions among the substrains of inbred Dahl S and R rats, we determined biochemical and immunological alleles of DIS/Eis and DIR/Eis, and SS/Sea and SR/Sea, which were derived from SS/Jr and SR/Jr, which were developed by Rapp and Dene. Several differences of allele distribution were observed, indicating that the substrains have different genetic backgrounds. The phenotypic differences between the substrains, such as the severity of the hypertension induced, could be ascribed to the different genetic backgrounds.
达尔-岩井盐敏感（S）和盐抵抗（R）大鼠品系在纽约布鲁克海文国家实验室被培育成近交系，随后引入日本卫材株式会社，并分别命名为DIS/Eis和DIR/Eis。为了研究近交系达尔盐敏感和盐抵抗大鼠的亚系之间是否存在不同的等位基因分布，我们测定了DIS/Eis和DIR/Eis以及SS/Sea和SR/Sea的生化和免疫等位基因，这些亚系源自由拉普和德内培育的SS/Jr和SR/Jr。观察到等位基因分布存在一些差异，表明这些亚系具有不同的遗传背景。亚系之间的表型差异，如诱导高血压的严重程度，可能归因于不同的遗传背景。
