Santos B R, Monteiro M G, Thomasson H R
Department of Pharmacology, Universidade Federal de Uberlandia, Minas Gerais, Brazil.
Alcohol. 1997 May-Jun;14(3):205-7. doi: 10.1016/s0741-8329(96)00066-3.
We determined the genotypes of the alcohol dehydrogenase (ALDH) and aldehyde dehydrogenase (ALDH2) loci of different ethnic groups living in Brazil, using saliva DNA amplified by PCR and allele-specific oligonucleotides. Self-reports of flushing reaction after drinking were also studied. The allelic frequencies of ADH2 and ALDH2 were found to be lower than those reported other authors, which might be a result of the admixture origin of the Brazilian population. Variability in facial flushing reaction suggests that other factors play a role in the expression of alcohol-induced flushing.
我们利用聚合酶链反应（PCR）扩增的唾液DNA和等位基因特异性寡核苷酸，确定了生活在巴西的不同种族群体的乙醇脱氢酶（ALDH）和乙醛脱氢酶（ALDH2）基因座的基因型。我们还研究了饮酒后脸红反应的自我报告。发现ADH2和ALDH2的等位基因频率低于其他作者报告的频率，这可能是巴西人群混合起源的结果。面部脸红反应的变异性表明，其他因素在酒精引起的脸红表达中起作用。
