Gauvin D V, Briscoe R J, Baird T J, Vallett M, Holloway F A
Department of Psychiatry & Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190-3000, USA.
Alcohol. 1997 May-Jun;14(3):261-8. doi: 10.1016/s0741-8329(96)00151-6.
The hedonic valence of EtOH's delayed effects, usually referred to as "hangover," was assessed 18 h after a 4 g/kg injection using both place and taste learning tasks. In the place conditioning task two CS-,CS+ intervals were used (48 h and 144 h); within each treatment interval, experimentally induced "hangover" was paired with the initially nonpreferred conditioning compartment for half of the experimental group (N = 10 rats) and with the initially preferred conditioning compartment for the half (N = 10 rats). Saline injections were paired with placement in the alternate conditioning compartment. A third group (N = 10 rats) was conditioned with milliliter equivalent volumes of saline on both sides. A conditioned place preference was conditioned with the hangover state-induced interoceptive stimuli. Attempts were made to taste condition 24 rats with the interoceptive stimulus attributes of hangover. Experimentally induced hangover was associated with an adipsogenic state, defined as a significant decline in voluntary intake of both saccharin and water, which prevented taste conditioning.
使用位置和味觉学习任务，在注射4 g/kg乙醇18小时后，评估乙醇延迟效应（通常称为“宿醉”）的享乐价。在位置条件反射任务中，使用了两个CS-、CS+间隔（48小时和144小时）；在每个治疗间隔内，对于一半实验组（N = 10只大鼠），将实验诱导的“宿醉”与最初不喜欢的条件化隔室配对，对于另一半（N = 10只大鼠），将其与最初喜欢的条件化隔室配对。注射生理盐水与放置在交替的条件化隔室中配对。第三组（N = 10只大鼠）在两侧用等量体积的生理盐水进行条件化。通过宿醉状态诱导的内感受性刺激建立条件性位置偏好。尝试用24只大鼠进行宿醉的内感受性刺激属性的味觉条件化。实验诱导的宿醉与厌饮状态相关，厌饮状态定义为糖精和水的自愿摄入量显著下降，这妨碍了味觉条件化。
