Rowe-Jones J M, Shembekar M, Trendell-Smith N, Mackay I S
Department of Otorhinolaryngology, Charing Cross Hospital, London, UK.
Clin Otolaryngol Allied Sci. 1997 Apr;22(2):167-71. doi: 10.1046/j.1365-2273.1997.00003.x.
The eosinophil may play a key role in the pathogenesis of nasal polyposis. Polyps in cystic fibrosis, however, have been described as neutrophilic. We compared the cell counts in polyps from 44 patients with cystic fibrosis to polyps from 50 patients without cystic fibrosis. The clinical profile, CT-scan and time to polyp recurrence were also compared with the cell counts in the patients with cystic fibrosis. No significant difference was detected in the number of patients with eosinophils (P > 0.25). Significantly more patients in the group with cystic fibrosis had polyp neutrophils (P < 0.01). Polyps from patients without cystic fibrosis contained more eosinophils (P < 0.001) whilst polyps from patients with cystic fibrosis contained more neutrophils (P = 0.001) and plasma cells (P = 0.038). Significant correlation was found between the neutrophil count and the CT score (P = 0.025) and between the recurrence time of polyps and the macrophage count (P = 0.01). Eosinophils are present in varying degrees in polyps from patients with and without cystic fibrosis and to classify polyps as eosinophilic or neutrophilic may be a false distinction.
嗜酸性粒细胞可能在鼻息肉病的发病机制中起关键作用。然而，囊性纤维化患者的息肉被描述为嗜中性的。我们比较了44例囊性纤维化患者的息肉与50例非囊性纤维化患者的息肉中的细胞计数。还将囊性纤维化患者的临床特征、CT扫描结果和息肉复发时间与细胞计数进行了比较。嗜酸性粒细胞患者数量未检测到显著差异（P>0.25）。囊性纤维化组中息肉嗜中性粒细胞的患者明显更多（P<0.01）。非囊性纤维化患者的息肉含有更多嗜酸性粒细胞（P<0.001），而囊性纤维化患者的息肉含有更多嗜中性粒细胞（P = 0.001）和浆细胞（P = 0.038）。发现嗜中性粒细胞计数与CT评分之间存在显著相关性（P = 0.025），息肉复发时间与巨噬细胞计数之间也存在显著相关性（P = 0.01）。囊性纤维化患者和非囊性纤维化患者的息肉中均存在不同程度的嗜酸性粒细胞，将息肉分类为嗜酸性或嗜中性可能是一种错误的区分。
