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Accumulation of Ade+ reversions in isoauxotrophic stains of Saccharomyces cerevisiae allelic in RAD6 during adenine starvation.

作者信息

Storchová Z, Gil A P, Janderová B, Vlasák J, Vondrejs V

机构信息

Department of Genetics and Microbiology, Faculty of Science, Charles University, Prague, Czech Republic.

出版信息

Folia Microbiol (Praha). 1997;42(1):47-51.

PMID:9161002
Abstract

A comparative method based on an analysis of accumulation of starvation-induced Ade+ reversions and cell death during adenine starvation was developed and exploited for estimating the role of RAD6 in the starvation-induced reversions. It was shown that inactivation of RAD6 function in Saccharomyces cerevisiae markedly enhances the accumulation of Ade+ reversions, and therefore it is likely that this gene is taking part in maintaining the low level of starvation-induced mutations in yeast cells.

摘要

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