Ueda J, Nakanishi H, Miyazaki M, Abe Y
Jpn Circ J. 1977 Sep;41(9):991-8. doi: 10.1253/jcj.41.991.
The effect of glucagon on the renal hemodynamics in the dog was examined by comparing its effect with that of secretin, a peptide with which glucagon shares a similar chemical structure. An intrarenal infusion of glucagon resulted in increases of RBF and GFR. GFR rose by approximately the same order of magnitude of RBF. The increase in GFR depended on the selective dilation of the afferent arteriole and a consequent rise in the transcapillary pressure difference. On the other hand, secretin infusion produced highly significant and proportional decreases in both afferent and efferent arteriolar resistance, resulting in no change in GFR. A superimposition of acetylcholine to glucagon decreased GFR even though RBF increased significantly. Glucagon infusion did not affect the permeability of glomerular capillary and the distribution of cortical blood flow. These findings indicate that the effect of glucagon on GFR depended on the selective dilation of afferent arteriole, and that as a result of its dilation the net filtration pressure increased without any change in permeability of glomerular capillary and a redistribution of filtration.
通过将胰高血糖素的作用与促胰液素（一种与胰高血糖素具有相似化学结构的肽）的作用进行比较，研究了胰高血糖素对犬肾血流动力学的影响。肾内输注胰高血糖素导致肾血流量（RBF）和肾小球滤过率（GFR）增加。GFR升高的幅度与RBF大致相同。GFR的增加取决于入球小动脉的选择性扩张以及由此导致的跨毛细血管压差升高。另一方面，输注促胰液素使入球和出球小动脉阻力均显著且成比例降低，导致GFR无变化。即使RBF显著增加，将乙酰胆碱与胰高血糖素叠加也会降低GFR。输注胰高血糖素不影响肾小球毛细血管通透性和皮质血流分布。这些发现表明，胰高血糖素对GFR的影响取决于入球小动脉的选择性扩张，并且由于其扩张，净滤过压增加，而肾小球毛细血管通透性和滤过分布无任何变化。
