Imatdieva R M, Gatsura V V
Eksp Klin Farmakol. 1997 Jan-Feb;60(1):32-4.
The effect of fructose-1, 6-diphosphate (200 mg/kg), cytochrome C (20 mg/kg) and their combinations on the size of the zone of necrosis 4 and 72 h after 15-min transitory myocardial ischemia was studied. Combination of the compounds under study inhibited considerably the development of post-occlusion and reperfusion arrhythmias and reduced the size of necrosis 4 h after their administration as prophylactic and arresting measures (to 23.8 +/- 2.9 and 29.3 +/- 3.6% of the ischemic zone, respectively, in 42.8 +/- 3.8% in the control). A combined course of cytochrome C and fructose diphosphate also limited the size of the necrotic zone 72 h after transitory ischemia. Separate single administration of fructose diphosphate and cytochrome C caused no essential changes in the size of myocardial necrosis recorded 72 h after transitory myocardial ischemia.
研究了1,6 - 二磷酸果糖（200mg/kg）、细胞色素C（20mg/kg）及其组合对15分钟短暂性心肌缺血后4小时和72小时坏死区域大小的影响。作为预防性和急救措施，所研究的化合物组合在给药后显著抑制了闭塞后和再灌注心律失常的发生，并减小了4小时后的坏死区域大小（分别为缺血区域的23.8±2.9%和29.3±3.6%，而对照组为42.8±3.8%）。细胞色素C和二磷酸果糖联合疗程也限制了短暂性缺血72小时后的坏死区域大小。单独单次给予二磷酸果糖和细胞色素C，在短暂性心肌缺血72小时后记录的心肌坏死大小无显著变化。
