[The effect of fructose-1,6-diphosphate, cytochrome c and their combination on the size of the necrotic area in transient myocardial ischemia].

The effect of fructose-1, 6-diphosphate (200 mg/kg), cytochrome C (20 mg/kg) and their combinations on the size of the zone of necrosis 4 and 72 h after 15-min transitory myocardial ischemia was studied. Combination of the compounds under study inhibited considerably the development of post-occlusion and reperfusion arrhythmias and reduced the size of necrosis 4 h after their administration as prophylactic and arresting measures (to 23.8 +/- 2.9 and 29.3 +/- 3.6% of the ischemic zone, respectively, in 42.8 +/- 3.8% in the control). A combined course of cytochrome C and fructose diphosphate also limited the size of the necrotic zone 72 h after transitory ischemia. Separate single administration of fructose diphosphate and cytochrome C caused no essential changes in the size of myocardial necrosis recorded 72 h after transitory myocardial ischemia.