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[果糖-1,6-二磷酸和磷酸烯醇丙酮酸对大鼠早期闭塞及再灌注心律失常进程的影响]

[The effect of fructose-1,6-diphosphate and phosphoenolpyruvate on the course of early occlusion and reperfusion arrhythmias in rats].

作者信息

Balashov V P, Kostin Ia V, Sedova D G, Sernov L N, Gatsura V V

出版信息

Biull Eksp Biol Med. 1993 Jun;115(6):629-30.

PMID:8374147
Abstract

Fructose-1,6-diphosphate (150 and 50 mg/kg) and phosphoenolpyruvate (0.5 and 0.1 mg/kg) decreased the development of ventricular tachycardia, ventricular fibrillation and the intensity of ventricular extrasystoles after coronary occlusion in experimental rats. Both compounds were active as anti-fibrillation agents on reperfusion arrhythmias. Fructose-1,6-diphosphate potentiated the effect of lidocaine.

摘要

1,6 - 二磷酸果糖(150毫克/千克和50毫克/千克)以及磷酸烯醇丙酮酸(0.5毫克/千克和0.1毫克/千克)可减少实验大鼠冠状动脉闭塞后室性心动过速、心室颤动的发生以及室性期前收缩的强度。这两种化合物对再灌注心律失常均有抗纤颤作用。1,6 - 二磷酸果糖增强了利多卡因的效果。

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