Novikov V E, Kovaleva L A
Eksp Klin Farmakol. 1997 Jan-Feb;60(1):59-61.
An open craniocerebral trauma was simulated in rat experiments. Oxidative phosphorylation in the brain mitochondria was studied by polygraphy 24 h after the trauma. It was found that trauma to the brain leads to inhibition of respiration in mitochondria in various metabolic states. Nooglutil in a dose of 50 mg/kg prevents these changes. Nooglutil is more effective than picamilon (500 mg/kg) and piriditol (100 mg/kg).
在大鼠实验中模拟开放性颅脑创伤。创伤后24小时通过多导仪研究脑线粒体中的氧化磷酸化。发现脑创伤会导致处于各种代谢状态的线粒体呼吸受到抑制。剂量为50mg/kg的脑复新可防止这些变化。脑复新比匹卡米隆（500mg/kg）和吡啶醇（100mg/kg）更有效。
