Schimmöller F, Itin C, Pfeffer S
Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA.
Curr Biol. 1997 Apr 1;7(4):R235-7. doi: 10.1016/s0960-9822(06)00109-6.
The budding of transport vesicles from the Golgi complex is initiated by activation of the small GTPase ARF; the discovery of enzymes that can convert soluble ARF-GDP to the active, membrane-associated form ARF-GTP will shed light on the mechanism and regulation of the formation of transport vesicles.
来自高尔基体复合物的运输小泡的出芽是由小GTP酶ARF的激活引发的；能够将可溶性ARF-GDP转化为活性的、与膜相关形式的ARF-GTP的酶的发现将阐明运输小泡形成的机制和调控。
