Kuehn M J, Schekman R
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.
Curr Opin Cell Biol. 1997 Aug;9(4):477-83. doi: 10.1016/s0955-0674(97)80022-1.
Yeast cylosolic coat proteins (COPII) direct the formation of vesicles from the endoplasmic reticulum. The vesicles selectively capture both cargo molecules and the secretory machinery that is necessary for the fusion of the vesicle with the recipient compartment, the Golgi apparatus. Recent efforts have aimed to understand how proteins are selected for inclusion into these vesicles. A variety of cargo adaptors may concentrate and sort secretory and membrane proteins by direct or indirect interaction with a subset of coat protein subunits.
酵母细胞质衣被蛋白（COPII）指导内质网形成囊泡。这些囊泡选择性地捕获货物分子以及囊泡与受体区室（高尔基体）融合所必需的分泌机制。最近的研究致力于了解蛋白质是如何被选择纳入这些囊泡的。多种货物衔接蛋白可通过与衣被蛋白亚基的一个子集直接或间接相互作用来浓缩和分选分泌蛋白和膜蛋白。
