Goldsmith H S
Boston University School of Medicine, MA 02118, USA.
Neurol Res. 1996 Apr;18(2):103-8. doi: 10.1080/01616412.1996.11740387.
A patient with Alzheimer's disease of long standing was treated with omental transposition to his brain. The rational for the procedure was to use the omentum to increase cerebral blood flow and to augment cholinergic neurotransmission activity. The patient improved for a year following surgery but after that time slowly began to decline neurologically and cognitively. However, according to Alzheimer's specialists who have followed the patient pre and postoperatively, he still maintains, 2.5 years after surgery, a higher level of performance than expected. There is theoretical and now a clinical suggestion that the omentum might play some role in the treatment of Alzheimer's disease. In view of the devastating nature of the disease, it seems reasonable to suggest that a limited controlled study be carried out to support or negate the benefit of the operation.
一位患有长期阿尔茨海默病的患者接受了大网膜移植至脑部的治疗。该手术的原理是利用大网膜增加脑血流量并增强胆碱能神经传递活动。患者术后改善了一年，但此后神经和认知功能开始缓慢衰退。然而，据跟踪该患者术前和术后情况的阿尔茨海默病专家称，术后2.5年，他的表现仍高于预期水平。有理论以及现在的临床迹象表明，大网膜可能在阿尔茨海默病的治疗中发挥某种作用。鉴于该疾病的毁灭性本质，建议进行一项有限的对照研究以支持或否定该手术的益处似乎是合理的。
