Kozlov I D, Fomina R F, Apanasevich V V, Filatova V N, Avramenko T V
Ter Arkh. 1997;69(1):14-7.
Multifactorial prophylaxis on the individual basis was conducted for 5 years among the population of 2047 males aged 40-59 years with ischemic heart disease (IHD) or its risk factors. Compared to the comparison group of 2101 subjects, in the study group the investigators achieved a 37% reduction in the mean population profile of myocardial infarction risk due to less prevalence of 3 main risk factor: arterial hypertension, low physical activity, smoking. Unbalance of the groups by age and education made the effect of the prevention measures on cardiovascular mortality menostrable only at statistical Cox's model.
对2047名年龄在40 - 59岁、患有缺血性心脏病(IHD)或有其危险因素的男性人群进行了为期5年的个体多因素预防。与2101名受试者的对照组相比,在研究组中,由于三种主要危险因素(动脉高血压、低体力活动、吸烟)的患病率较低,研究人员使心肌梗死风险的平均人群概况降低了37%。两组在年龄和教育程度上的不均衡使得预防措施对心血管死亡率的影响仅在统计Cox模型中得以显现。