Janes S L, Pocock M, Bishop E, Bevan D H
Department of Haematology, St George's Hospital Medical School, London.
Br J Haematol. 1997 May;97(2):256-8. doi: 10.1046/j.1365-2141.1997.322675.x.
Red cell exchange is important in the care of acutely ill sickle-cell patients, and may be life-saving. An automated red cell exchange technique has been developed using a Baxter blood cell separator, enabling an isovolaemic exchange to be performed within 2.5 h. A total of 20 procedures have been performed in 15 patients, including one woman in the third trimester of pregnancy, with a mean decrease of 72% in the circulating sickle haemoglobin (HbS) level. This method enables almost all adult patients with sickle cell anaemia to have their HbS reduced to safe levels by only one procedure. The procedure was well tolerated by all patients, including those who were acutely ill. This technique provides an effective procedure for reducing the percentage of circulating HbS rapidly in acutely ill patients with complications of sickle cell anaemia.
红细胞置换对于急性病镰状细胞患者的治疗很重要，可能挽救生命。已研发出一种使用百特血细胞分离机的自动化红细胞置换技术，能在2.5小时内完成等容置换。15名患者共进行了20次该操作，其中包括一名孕晚期女性，循环镰状血红蛋白（HbS）水平平均降低了72%。此方法能让几乎所有成年镰状细胞贫血患者仅通过一次操作就将其HbS降至安全水平。所有患者，包括急性病患者，对该操作耐受性良好。这项技术为快速降低急性病镰状细胞贫血并发症患者循环HbS的百分比提供了一种有效方法。
