Tohyama K, Satomi G, Momma K
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical College.
Am J Cardiol. 1997 May 1;79(9):1285-9. doi: 10.1016/s0002-9149(97)00105-7.
The natural development of aortic valve deformity was studied in 315 patients with subpulmonic ventricular septal defect. The patients with early development of aortic regurgitation had a pulmonary-to-systemic flow ratio of > 1.5, normal right ventricular pressure, and severe aortic regurgitation.