Viscomi C M, Bailey P L
Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, USA.
Obstet Gynecol. 1997 May;89(5 Pt 2):822-4. doi: 10.1016/s0029-7844(97)81423-8.
Large doses of intravenous opioids may cause severe rigidity and prevent spontaneous or controlled ventilation. The mechanism of this effect appears to be neuraxis dopamine antagonism. Rigidity after analgesic doses of fentanyl has not been reported previously.
A pregnant woman receiving haloperidol for multiple psychiatric conditions presented for evaluation of vaginal bleeding. Intravenous fentanyl was administered to facilitate vaginal examination. Severe rigidity of the extremities and truncal region occurred, which prevented spontaneous or assisted ventilation.
Opioid administration may result in rigidity and respiratory embarrassment. Decreased analgesic requirements in pregnancy and concomitant butyrophenone administration may predispose to opioid-induced rigidity.
大剂量静脉注射阿片类药物可能导致严重的强直，并妨碍自主或控制通气。这种效应的机制似乎是神经轴多巴胺拮抗作用。此前尚未有关于镇痛剂量芬太尼后发生强直的报道。
一名因多种精神疾病接受氟哌啶醇治疗的孕妇因阴道出血前来评估。静脉注射芬太尼以利于阴道检查。随后出现四肢和躯干严重强直，妨碍了自主或辅助通气。
使用阿片类药物可能导致强直和呼吸窘迫。孕期镇痛需求降低以及同时使用丁酰苯类药物可能易引发阿片类药物所致的强直。
